AFREZZA® Access and Support Through MannKind Cares®

For US healthcare professionals only
Request a Rep
provides the support you need

MannKind Cares helps simplify the path from prescription to fulfillment

Savings programs

Prior authorization support

Convenient home delivery

Patient Navigators to support training and access needs

provides the support you need

MannKind Cares helps simplify the path from prescription to fulfillment

Savings programs

Prior authorization support

Convenient home delivery

Patient Navigators to support training and access needs

Prescribe and enroll

Prescribe AFREZZA® and enroll patients through MannKind Cares

Once you have selected the appropriate AFREZZA dose and written the prescription, MannKind Cares can help support the next steps, including coverage, access, affordability, and fulfillment.

CALCULATE DOSE NOW

To access the full support of MannKind Cares, create and submit your prescription through one of the following ways:

1
Online: Visit the online portal at mannkindcaresrx.com
VISIT MANNKINDCARESRX
2
Fax: Download the form at mannkindcaresrx.com and fax the completed form to 800-561-6174
VISIT MANNKINDCARESRX
3
eRx: Submit via EMR by selecting Autopilot Rx pharmacy from your EMR drop-down
  • NABP: 0364721
  • NPI: 1821677154

Call MannKind Cares if you have questions

Phone: 844-323-7399 (Hours: Monday through Friday, 8:00 AM to 8:00 PM ET)

Access and affordability

Affordability options are primarily available to your patients directly through MannKind Cares

New patients 6 to 23 years

New patients 6 to 23 years

Pediatric Cash Pay
Bridge Programa

$ 35 or less

per monthb

New patients ≥24 years and existing patients

Commercial and Medicare Part D Approved

Pay as
little as
$ 35

per month

Cash Pay Option

Pay
$ 99

per box

If going outside of MannKind Cares, all commercially insured patients can download the AFREZZA Savings Card at www.afrezzasavingscard.com.

aPediatric Bridge Program is effective from June 1, 2026, to December 31, 2026.
bFor eligible patients and is available exclusively through MannKind Cares.

$35 Pediatric Cash Pay Bridge Program T&C: The AFREZZA Pediatric Cash Pay Bridge Program (“Program”) is valid ONLY for new patients who are prescribed AFREZZA and age 23 years or younger. The Program is available exclusively through the MannKind Cares hub. The Program cannot be combined with any other coupon, discount, prescription savings card, or other offer. The Program is not available for patients receiving reimbursement for the entire cost of their prescription drug. Patients or their caregiver/legal guardian cannot seek reimbursement from health insurance or any third party for any part of the assistance received through this Program. The patient or his/her caregiver/legal guardian is responsible for reporting the receipt of all benefits or reimbursement received under the Program to any insurer, health plan, or other third party, as may be required. The Program assists with the cost of AFREZZA only. It does not assist with the cost of other medicines, procedures, or office visits. MannKind reserves the right to terminate, rescind, revoke, or modify the Program at any time without notice. The Program expires 12/31/2026. This Program is valid only in the United States and its territories. Void where prohibited by law. Call MannKind Cares at 844-323-7399, 8:00 AM to 8:00 PM ET, Monday through Friday, with questions.

What does AFREZZA cost for patients, and what affordability support is available?

MannKind Cares® offers affordability options for eligible patients. New patients ages 6 to 23 years may qualify for the Pediatric Cash Pay Bridge Program and pay $35 or less per month. New patients ≥24 years and existing patients who are commercially insured or Medicare Part D approved may pay as little as $35 per month. Eligible cash-pay patients may pay $99 per box. If patients go outside MannKind Cares, commercially insured patients can download the AFREZZA Savings Card. Eligibility and program terms apply.

Indications and Usage:

Afrezza® (insulin human) Inhalation Powder is a rapid acting inhaled human insulin indicated to improve glycemic control in adult and pediatric patients 6 years of age and older with diabetes mellitus.

Limitations of Use: Not recommended for the treatment of diabetic ketoacidosis, not recommended in patients who smoke or have recently stopped smoking.

Important Safety Information

WARNING: RISK OF ACUTE BRONCHOSPASM IN PATIENTS WITH CHRONIC LUNG DISEASE

  • Acute bronchospasm has been observed in AFREZZA-treated patients with asthma and Chronic Obstructive Pulmonary Disease (COPD).
  • AFREZZA is contraindicated in patients with chronic lung disease such as asthma or COPD.
  • Before initiating AFREZZA, perform a detailed medical history, physical examination, and spirometry (FEV1) to identify potential lung disease in all patients.

Indications and Usage:

Afrezza® (insulin human) Inhalation Powder is a rapid acting inhaled human insulin indicated to improve glycemic control in adult and pediatric patients 6 years of age and older with diabetes mellitus.

Limitations of Use: Not recommended for the treatment of diabetic ketoacidosis, not recommended in patients who smoke or have recently stopped smoking.

Important Safety Information

WARNING: RISK OF ACUTE BRONCHOSPASM IN PATIENTS WITH CHRONIC LUNG DISEASE

  • Acute bronchospasm has been observed in AFREZZA-treated patients with asthma and Chronic Obstructive Pulmonary Disease (COPD).
  • AFREZZA is contraindicated in patients with chronic lung disease such as asthma or COPD.
  • Before initiating AFREZZA, perform a detailed medical history, physical examination, and spirometry (FEV1) to identify potential lung disease in all patients.

Contraindications

AFREZZA is contraindicated: during episodes of hypoglycemia, in patients with chronic lung disease (such as asthma or COPD) because of the risk of acute bronchospasm, and in patients with previous severe hypersensitivity reaction to any regular human insulin product or any of the inactive ingredients in AFREZZA. Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with AFREZZA.

Warnings and Precautions

Acute Bronchospasm in Patients with Chronic Lung Disease: In a study of patients with asthma whose bronchodilators were temporarily withheld for assessment, bronchoconstriction and wheezing following AFREZZA dosing was reported. Before initiating therapy, evaluate all patients with a medical history, physical examination, and spirometry (FEV1) to identify potential underlying lung disease. Do not use in patients with chronic lung disease such as asthma or COPD.

Hypoglycemia or Hyperglycemia with Changes in Insulin Regimen: Changes in an insulin regimen (e.g., insulin strength, manufacturer, injection site or type, or method of administration) may affect glycemic control and predispose to hypoglycemia or hyperglycemia. If clinically indicated, make any necessary changes to a patient's insulin regimen under close medical supervision with increased frequency of blood glucose monitoring. For patients with type 2 diabetes dosage modification of concomitant oral antidiabetic treatment may be needed.

Hypoglycemia: Hypoglycemia is the most common adverse reaction associated with insulins, including AFREZZA. Severe hypoglycemia can cause seizures, may be life-threatening, or cause death. Hypoglycemia can impair concentration ability and reaction time; this may place an individual and others at risk in situations where these abilities are important (e.g., driving or operating other machinery). Hypoglycemia can happen suddenly, and symptoms may differ across patients and change over time in the same patient. Advise patients to recognize and manage hypoglycemia and self-monitor glucose. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of glucose monitoring is recommended.

Decline in Pulmonary Function: AFREZZA causes a decline in lung pulmonary function over time as measured by FEV1. In clinical trials excluding patients with chronic lung disease and lasting up to 2 years, AFREZZA-treated patients experienced a small (40 mL) but greater FEV1 decline than comparator-treated patients. Assess pulmonary function with spirometry at baseline, after the first 6 months of therapy and annually thereafter even in the absence of pulmonary symptoms. In patients who have a decline of ≥20% in FEV1 from baseline, consider discontinuing AFREZZA. Consider more frequent lung function assessment in patients with pulmonary symptoms, e.g., wheezing, bronchospasm, breathing difficulties, or persistent or recurring cough. If symptoms persist, discontinue AFREZZA.

Lung Cancer: In clinical trials, 2 cases of lung cancer were observed in patients exposed to AFREZZA while no cases were reported for the comparators. In both cases, a prior history of heavy tobacco use was identified as a risk factor for lung cancer. Two additional cases of lung cancer (squamous cell and lung blastoma) were reported in non-smokers exposed to AFREZZA after the trial completion. These data are insufficient to determine whether AFREZZA has an effect on lung or respiratory tract tumors. In patients with active lung cancer, a prior history of lung cancer, or in patients at risk of lung cancer, consider whether the benefits of AFREZZA use outweigh this potential risk.

Diabetic Ketoacidosis (DKA): In clinical trials enrolling patients with type 1 diabetes, diabetic ketoacidosis (DKA) was more common in AFREZZA-treated patients (0.43%; n=13) than in comparator-treated patients (0.14%; n=3). Patients with type 1 diabetes should always use AFREZZA concomitantly with basal insulin. In patients at risk for DKA, such as those with an acute illness or infection, increase the frequency of glucose monitoring and consider discontinuing AFREZZA and giving insulin using an alternate route of administration.

Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with insulin products. If hypersensitivity reactions occur, discontinue AFREZZA, treat per standard of care and monitor until symptoms and signs resolve.

Hypokalemia: All insulin products, including AFREZZA, cause a shift in potassium from the extracellular to intracellular space, possibly leading to hypokalemia. Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death. Closely monitor potassium levels in patients at risk of hypokalemia and treat if indicated.

Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin. Fluid retention may lead to or exacerbate heart failure. Observe these patients for signs and symptoms of heart failure. If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the TZD should be considered.

Adverse Reactions

The most common adverse reactions associated with AFREZZA are hypoglycemia, cough, and throat pain or irritation.

Drug Interactions

Certain drugs may affect glucose metabolism, increasing the risk of hypoglycemia, or decreasing or increasing the blood glucose lowering effect of AFREZZA. Dosage modification and increased frequency of blood glucose monitoring may be required. Co-administration of beta-blockers, clonidine, guanethidine, and reserpine with AFREZZA may reduce the signs and symptoms of hypoglycemia. For full list, see Prescribing Information.

To report SUSPECTED ADVERSE REACTIONS, contact MannKind Corporation at 1-877-323-8505 or FDA at www.fda.gov/medwatch or call 1-800-FDA-1088 (1-800-332-1088).

Please see full Prescribing Information, including BOXED WARNING for AFREZZA.