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Proven A1C control2,3

AFREZZA effectively lowers A1C in T1D and T2D patients2,3

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Post-mealtime control4

AFREZZA significantly decreases PPG excursions after meals.4

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Less risk of hypoglycemia5

AFREZZA reduced risk of hypoglycemic events compared with SC RAIs5

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A1C=glycated hemoglobin; FPG=fasting plasma glucose; PPG=postprandial glucose; SC RAI=subcutaneous rapit-acting insulin; T2D=type 2 diabetes.

References: 1. American Diabetes Association Professional Practice Committee. Diabetes Care. 2024; 47 (Supplement_1): S111–S125. 2. Levin P, Hoogwerf BJ, Snell-Bergeon J, Vigers T, Pyle L, Bromberger L. Ultra rapid-acting inhaled insulin improves glucose control in patients with type 2 diabetes mellitus. Endocr Pract. 2021;27(5):449-454. 3. Bode BW, McGill JB, Lorber DL, Gross JL, Chang PC, Bregman DB. Inhaled Technosphere insulin compared with injected prandial insulin in type 1 diabetes: a randomized 24-week trial. Diabetes Care. 2015;38(12):2266-2273. 4. Akturk HK, Snell-Bergeon JK, Rewers A, et al. Improved postprandial glucose with inhaled Technosphere insulin compared with insulin aspart in patients with type 1 diabetes on multiple daily injections: the STAT study. Diabetes Technol Ther. 2018;20(10):639-647 5. Seaquist ER, Blonde L, McGill JB, et al. Hypoglycaemia is reduced with use of inhaled Technosphere® Insulinrelative to insulin aspart in type 1 diabetes mellitus. Diabet Med. 2020;37(5):752-759

© MannKind Corporation June, 2024. US-AFR-1643

Indications and Usage

Afrezza® (insulin human) Inhalation Powder is a rapid acting inhaled human insulin indicated to improve glycemic control in adult patients with diabetes mellitus.

Limitations of Use: Not recommended for the treatment of diabetic ketoacidosis, not recommended in patients who smoke or have recently stopped smoking.

Important Safety Information for Afrezza® (insulin human) Inhalation Powder

WARNING: RISK OF ACUTE BRONCHOSPASM IN PATIENTS WITH CHRONIC LUNG DISEASE. Acute bronchospasm has been observed in patients with asthma and COPD using AFREZZA. AFREZZA is contraindicated in patients with chronic lung disease such as asthma or COPD. Before initiating AFREZZA, perform a detailed medical history, physical examination, and spirometry (FEV1) to identify potential lung disease in all patients.